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【简答题】
，36岁。十二指肠溃疡病史4年，每年的初秋至次年早春多发，呈典型餐前及夜间上腹部疼痛，进餐后缓解，伴嗳气、返酸。2腹痛再发，近2日病人出现上腹持续性胀痛，餐后加重，伴呕吐大量酸、酵宿食。体检：体温36.8℃，脉膊80次/分，血压100/70mmHg。腹软，中上腹有轻度压痛，无反跳痛，肝脾未及，可见胃蠕动波及胃型，上腹部振水音阳性。该病人病情发生了什么变化？
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