【多选题】How is the nuclear envelope supported by a meshwork of intermediate filaments?
A.
Whereas cytoplasmic intermediate filaments form ropelike structures, the intermediate filaments lining and strengthening the inside surface of the inner nuclear membrane are organized as a two-dimensional meshwork.
B.
The intermediate filaments that form this tough nuclear lamina are constructed from a class of intermediate filament proteins called lamins (not to be confused with laminin, which is an extracellular matrix protein). The nuclear lamina disassembles and reforms at each cell division, when the nuclear envelope breaks down during mitosis and then re-forms in each daughter cell.
C.
The collapse and reassembly of the nuclear lamina is controlled by the phosphorylation and dephosphorylation of the lamins.
D.
Phosphorylation of lamins by protein kinases weakens the interactions between the lamin tetramers and causes the filaments to fall apart. Dephosphorylation by protein phosphatases at the end of mitosis allows the lamins to reassemble.