The major safety concerns with ALife & synthetic biology are:
A.
biosafety & biorisk: horizontal gene transfer, the formation of antibiotic-resistant superbugs, etc.
B.
bioterrorism (e.g. design & use of new biological weapons)
C.
biosecurity: synthesis of dangerous bacteria or viruses, e.g. poliovirus genome synthesized in 2002, the Spanish influenza virus genome synthesized in 2005, the SARS virus genome synthesized in 2008, the Ebola virus genome synthesized in 2016, & the horsepox virus genome synthesized in 2017
D.
environmental risk & impact: intentional or unintentional release of synthetic organisms into the environment