【多选题】How does regular exercise help control type 2 diabetes?
A.
Exercise activates AMPK, as does adiponectin; AMPK shifts metabolism toward fat oxidation and inhibits fat synthesis.
B.
Exercise consumes calories and in that way directly contributes to weight loss.
C.
Exercise also increases release of irisin from muscle into the blood.
D.
Irisin increases the expression of UCP1 genes in WAT and also stimulates the development of beige adipocytes, so even after the exercise ends, energy continues to be used in thermogenesis.