Which of the following is consistent with a model for aging in which stresses leading to DNA damage cause senescence?
A.
Werner's syndrome is a premature aging illness, possibly caused by a defect in DNA repair.
B.
Dietary restriction in mammals reduces the production of DNA damaging free radicals in the mitochondria.
C.
Senescent cells in culture that have stopped dividing often express p21 and p16, proteins that are normally activated in response to DNA damage.
D.
All of these facts are consistent with a model for aging based on DNA damage.