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【单选题】
细菌对青霉素产生耐药性的主要机制是
A.
细菌细胞膜对药物通透性改变
B.
细菌产生了水解酶
C.
细菌产生了大量PABA(对氨苯甲酸)
D.
细菌产生了钝化酶
E.
细菌的代谢途径改变
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