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【多选题】
改善固体药剂中药物溶出速度的方法有
A.
制成药物的微粉药物微粉化处理,增加表面积
B.
药物与水溶性辅料共同研磨制备研磨混合物,防止药物细小粒子的聚集
C.
制成固体分散体选用水溶性的高分子载体,使药物以分子、离子形式分散在其电
D.
从Noyes-Whitney方程说明药物从固体剂型中的溶出速度与溶出速度常数(k)、药物溶解度(Cs)成反比
E.
制成吸附于“载体”的混合物将难溶性药物先溶于能与水混溶的无毒溶剂中,再用多孔性载体将其吸附,药物以分子状态存在于载体中
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Because it is very far from here.
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