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【多选题】
有关栓剂中药物吸收，不正确的表述有()
A.
局部作用的栓剂，药物通常不需要吸收或应尽量减少吸收
B.
降低弱酸性药物的pH或升高弱碱性药物的pH均可增加吸收
C.
在油脂性基质中，加入表面活性剂的量越多，药物吸收越多
D.
基质的溶解特性正好与药物相反时，不利于药物的释放与吸收
E.
药物的粒径越小，表面积越大，越有利于药物的吸收
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