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【简答题】
（5分）2014年2月索契冬奥会胜利闭幕。俄罗斯人以其特有的幽默方式弥补了开幕式上的“失误四环”，完美的雪花五环终于绽放！下图便是“奥运五环”的连接方式，若圆和圆相交表示可以反应，“→”表示可以转化。请根据上述所给信息及相关要求回答下列问题： （1）选择氧气、二氧化碳、氧化铁、铁丝、稀硫酸、氢氧化钡溶液、碳酸钙几种物质中的五种并将其化学式（或主要成分的化学式）填入圆中，也形成一个完美的“五环”，并用“→” 画出几种物质间相互转化的关系； 已知A、B之间发生的是化合反应，该反应的实验现象是 ； 写出有白色沉淀生成的化学反应方程式 。
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【简答题】APC抵抗(resistance to activated protein C，APCR)
【单选题】根据《药品召回管理办法》规定，药品一级召回是指
A.
使用该药品一般不会引起健康危害的药品召回
B.
使用该药品可能引起暂时的健康危害的药品召回
C.
使用该药品可能引起可逆的健康危害的药品召回
D.
使用该药品可能引起严重的健康危害的药品召回
E.
和健康无关的其他原因需要收回的药品召回
【多选题】AMP-activated protein kinase (AMPK) is activated by ____________________.
A.
elevated [AMP]
B.
decreased [ATP]
C.
exercise
D.
the sympathetic nervous system (SNS) and peptide hormones produced in adipose tissue (leptin and adiponectin)
【多选题】What are peroxisome proliferator-activated receptors (PPARs) ?
A.
Proteins in a family of ligand-activated transcription factors known as peroxisome proliferator-activated receptors (PPARs) respond to changes in dietary lipid by altering the expression of genes involved in fat and carbohydrate metabolism.
B.
These transcription factors were first recognized for their roles in peroxisome synthesis—thus their name. They are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.
C.
Their normal ligands are fatty acids or fatty acid derivatives, but they can also bind synthetic agonists and can be activated in the laboratory by genetic manipulation. PPARα, PPARδ, and PPARγ are members of this nuclear receptor superfamily.
D.
They act in the nucleus by forming heterodimers with another nuclear receptor, RXR, then binding to regulatory regions of DNA near the genes under their control and changing the rate of transcription of those genes.
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