![](https://cos-cdn.shuashuati.com/pipixue-wap/2020-1230-1107-56/ti_inject-812ce.png)
As to CNS-targeted drug delivery, which of the following statements is NOT TRUE ?
A.
Blood brain barrier make the brain inaccessible to CNS-targeted drugs in the systemic circulation.
B.
Low-molecular and lipid-soluble drugs can rapidly cross blood brain barrier by passive diffusion
C.
It is more difficult to deliver biotherapeutics across blood brain barrier
D.
Increasing the hydrophilicity of a drug molecule is likely to increase its transport across the BB B