Heredity : The tendency to develop depression is inherited and may run in (1)__________ . Physiology : Depression may be caused by changes or imbalances in (2)___________ called neurotransmitters, which transmit (3)______________ in the brain. Antidepressant medications relieve (4)_______________ ___ of depression. Psychology : Low (5)______________ and self-defeating thinking are connected with depression. Sufferers who make corrections to their (6)____________ _______ can show improved (7)__________ and self-esteem. Early experiences : Events like the death of a parent, the (8)________ of the parents, neglect, chronic illness, and severe (9)_______________ can increase the likelihood of depression. Present experiences : Job loss, (10)___________________ , long periods of unemployment, the loss of a spouse or other family member, or long-term (11)_________ may trigger depression. Living with someone with depression : This causes increased (12)___________ for those who live with them.