A 30-year-old female patient presents with a new onset of peripheral edema. Physical examination finds hypertension and bilateral pedal edema. Urinalysis finds massive proteinuria, and evaluation of her serum finds elevated levels of cholesterol. A silver stain of a renal biopsy specimen reveals a characteristic “spike and dome” pattern, and electron microscopy finds a uniform deposition of small electron- dense deposits in a subepithelial location. Which of the following immunofluorescence patterns is most characteristic of this patient’s renal disease?
A.
Granular pattern of IgA and C3
B.
Granular pattern of IgG and C3
C.
Linear pattern of IgD and C4
D.
Linear pattern of IgE and C4
E.
Linear pattern of IgM and C3