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A 50-year-old woman with a history of unstable angina suffers an acute myocardial infarction. Thrombolytic therapy with tissue plasminogen activator (tPA) is administered to restore coronary blood flow. In spit e of this therapy, the degree of myocardial fiber injury may increase because of which of the following cellular abnormalities?
A.
Cytoskeletal intermediate filament loss
B.
Decreased intracellular pH from anaerobic glycolysis
C.
Increased free radical formation
D.
Mitochondrial swelling
E.
Nuclear chromatin clumping
F.
Reduced protein synthesis