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【多选题】
关于防止可溶性成分迁移正确叙述是A.
为了防止可溶性色素迁移产生“色斑”,最根本防止办法是选用不溶性色素
B.
采用微波加热干燥时,可使颗粒内部的可溶性成分减少到最小到最小的程度
C.
颗粒内部的可溶性成分迁移所造成的主要问题是片剂的含量均匀度
D.
采用箱式干燥时,颗粒之间的可溶性成分迁移现象最为明显
E.
采用流化(床)干燥法时,一般不会发生颗粒间的可溶性成分迁移,有利于提高片剂的含量均匀度,但仍有可能出现色斑或花斑
F.
:A,B,D,E
G.
、包衣主要是为了达到以下一些目的
H.
控制药物在胃肠道的释放部位
I.
控制药物在胃肠道中的释放速度
J.
掩盖苦味或不良气味 K. 防潮、避光、隔离空气以增加药物的稳定性 L. 防止松片现象
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