Which of the following statements regarding chronic bronchitis are TRUE:
A.
Chronic bronchitis is defined as persistent productive cough for at least 3 consecutive months in at least 2 consecutive years
B.
Cigarette smoking is the most important risk factor
C.
Air pollutants contribute to chronic bronchitis
D.
The dominant pathologic features are mucus hypersecretion and persistent inflammation
E.
Histologic examination demonstrates enlargement of mucous-secreting glands, goblet cell hyperplasia, chronic inflammation, and bronchiolar wall fibrosis