Which of the following statements about active center of enzyme is not true
A.
Binding of enzyme with substrate is limited to the small area of enzyme structure which is closely related to enzyme activity.
B.
The essential groups may locate either in or outside the active center.
C.
Usually consists of several amino acid residues adjacent to each other in the primary structure
D.
Zymogen activation is actually the process of forming complete active center.
E.
Binding of substrates can induce conformational change of the active center of enzyme.