Depression involves sadness, pessimism, a preoccupation with personal problems, and perhaps feeling sorry for one's self, anguish, crying, and hopelessness. Depressed people often lose interest in many activities and social 1 because of loss of pleasure in and enthusiasm for their usual activities. They may become apathetic or socially 2 . Low energy, chronic tiredness, 3 sleeping, and insomnia are common. Other possible symptoms of depression include poor appetite, heavy eating, weight loss or gain, feelings of 4 or worthlessness, anxiety, regrets, decreased productivity, poor concentration, or 5 thoughts of death or suicide. Four out of five cases of severe depression 6 without treatment within six to nine months, 7 half of the people with severe depression experience it again later. People often become depressed about marital, romantic, or family problems. For example, one study found an unhappy marriage increased the risk of clinical depression 25 times 8 untroubled marriages. A personal loss often 9 depression: divource, separation, loss of a job, the end of a love relationship, physical or mental problems from old age, the death of a loved one, etc. Many stressful events or major changes may also help 10 depression.