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【单选题】
Km值近似等于酶和底物结合生成的中间复合物[ES]的解离常数，下面叙述正确的是
A.
Km值大，酶和底物的亲和力越小
B.
Km值大，酶和底物的亲和力越大
C.
Km值小，酶和底物的亲和力越小
D.
Km值大，酶的催化活性高
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