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【单选题】
动物胰岛素与人的胰岛素结构有差异，有抗原性；胰岛素制剂中可能混有胰岛素原和其他杂蛋白，也有抗原性；胰岛素制剂加工浓缩工艺可能改变其三级结构、使抗原性增加。 “对人胰岛素过敏者可换用胰岛素类似物(重组胰岛素)”的依据是
A.
人胰岛素含有致敏杂质
B.
人胰岛素制品的添加剂致敏
C.
该批号人胰岛素质量不合格
D.
制备工艺致使人胰岛素结构改变
E.
制备人胰岛素浓缩工艺致使三级结构改变
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