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【单选题】
患者,女性,42岁,对称性全身小关节肿痛反复发作6年,有晨僵,热水浸泡后减轻,辅助检查:类风湿因子阳性。拟诊为类风湿关节炎。后期发现患者腕部及踝部出现结节,提示
A.
出现并发症
B.
病情减轻
C.
已累及内脏
D.
癌变
E.
病情活动
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