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【单选题】
女性，62岁，高血压、糖尿病史5年，4个月前开始有心绞痛，近1个月来心绞痛发作频繁、持续时间、严重程度均有所加重，昨晚8休息状态下出现压榨性心前区疼痛，胸骨后明显，向左上肢内侧放射，持续时间约20分钟，含服硝酸甘油效果不理想，故来急诊，入院后发作1次，心电图是V4～V5ST段下降1.5mm，心肌酶及肌钙蛋白不高。不稳定型心绞痛与非ST段抬高型心肌梗死的主要区别是（）
A.
疼痛持续时间&le；20分钟
B.
无血中心脏生物学标志物升高
C.
48小时内有多次心绞痛发作
D.
疼痛发作有明确的诱因
E.
在安静状态下发病
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