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【多选题】
1,4-苯并二氮卓类药物药效主要受哪些因素影响
A.
2位被吸电子基氯、三氟甲基取代，活性增加
B.
在1, 2-位骈合三唑环，提高了受体的亲和力，活性明显增加
C.
在1位引入哌嗪基，活性大大增加
D.
4, 5位双键被饱和，其活性大大降低
E.
7位引入吸电子基团硝基，可明显增强活性。
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