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【简答题】
提取基因组DNA后,如何检测DNA的质量?
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【简答题】基因治疗(gene therapy)
【简答题】基因治疗(Gene therapy)
【简答题】基因治疗(gene therapy)
【多选题】The major risks for gene therapy include:
A.
Gene therapy can trigger the immune response in the patient, that could be harmful to them. Retroviruses has raised skepticism about their safety. Deactivated viruses are really deactivated?
B.
Viral vectors may cause toxicity, infection, inflammation, etc.
C.
Gene therapy may cause off-target effects — there is a risk that the new gene will insert itself into the path of another gene, disrupting its activity, or cause insertional mutagenesis.
D.
Gene therapy may cause chronic granulomatous disease and cancer.
【多选题】Which of the following statements on gene therapy are correct?
A.
Two decades after the initial gene therapy trials and more than 2,000 approved clinical trials worldwide we not only have gained much new information and knowledge regarding gene therapy in general, but also learned to understand the concern that has persisted in society.
B.
Nevertheless, our knowledge continues to grow and during the course of time more safety data has become available that helps us to develop better gene therapy approaches. Also, with the increased understanding of molecular medicine, we have been able to develop more specific and efficient gene transfer vectors which are now producing clinical results.
C.
Despite the setbacks gene therapy has faced, success stories have increasingly emerged. Without doubt, the ethical aspects regarding gene therapy need to be addressed the same way as the question about their efficacy and safety.
D.
We need to acknowledge the fear of some patients in respect to gene therapy. Ultimately it is the patient who decides, whether she/he wants to be treated with gene therapy.
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